Design, Synthesis, and Biological Evaluation of AT1 Angiotensin II Receptor 2 Substituted phenyl- (phenyl-{1- [2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]- 1H-benzoimidazol-5-ylamine
نویسندگان
چکیده
Synthesis of a series of novel substituted benzimidazole derivatives by the condensation of ophenylenediamine (OPDA,) with Mandlic acid and subsequent reactions of the benzimidazole with different amino substituted is reported with reaction biphenyl tetrazole. All the compounds synthesized were screened for their potential anti-hypertensive properties,
منابع مشابه
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF SOME BENZYLIDENE-(2-{5, 6-SUBSTITUTED-1-[2-(1H-TETRAZOL-5-yl)-BIPHENYL-4- YLMETHYL]-1H-BENZOIMIDAZOL-2-YL}-PHENYL-AMINE IN THE PRESENCES OF BF3·OET2 CATALYSTS AS ANTIHYPERTENSIVE AGENTS
A series of Benzylidene-(2-{5, 6-substituted-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-2-yl}-phenyl-amine have been synthesized by 4'-{2-[2-(Benzylideneamino)-phenyl] 5, 6-substitutedbenzimidazol-1-yl}-biphenyl-2-carbonitrile.Preliminary screening of the title compounds for antihypertensive activity was performed. Only one of the compound was found to possess antihypertensive...
متن کاملSynthesis and Biological Evaluation 6-chloro-2-substitued-1-[2-(1h- Tetrazol-5-yl)-biphenyl-4-ylmethyl]-1h-benzoimidazol-5-ylamine Antihypertensive Agents
A series of methyl 6-Chloro-2-Substitued-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-5-ylamine were successfully synthesized. Benzimidazoles were prepared by condensation of 4-chloro-o-phenylenediamine with substituted aryl, aldehyde condensation with biphenyl tetrazole group and reduction stannous chloride dihydrate. An insertion-cyclization strategy was involved during synthe...
متن کاملSynthesis and pharmacological activity of 2-(2-substituted-phenyl)-3-(4-{1-[2- (1H-tetrazol-5-yl)-biphenyl-4-ylmethyl])-1H-benzoimidazol-2-yl}-phenyl)- thiazolidin-4-ones
An easy and efficient method to obtain Schiff bases of [2-(2-substituted-phenyl)-3-(4-{1-[2-(1Htetrazol-5-yl)-biphenyl-4-ylmethyl])-1H benzoimidazol-2-yl}-phenyl)thiazolidin-4-one] using different aromatic aldehydes. Reaction mixture of Schiff base (0.01 mol) and mercaptoacetic acid (0.05 mol) dissolved in dioxane (50 ml), anhydrous zinc chloride (0.008 mol) was added and refluxed for 12 hrs. T...
متن کاملSynthesis and Antihypertensive Activity of Some N-{4-(6-Chloro-5-nitro-1- [2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazol-2yl-}-phenyl)- 3-(substituted-phenyl)-acryl amides
A new series of N-{4-(6-Chloro-5-nitro-1-[2'--(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1Hbenzoimidazol-2yl-}-phenyl)-3-(substituted-phenyl)-acryl amide derivatives [1-8] has been synthesized and subjected to evaluate their antihypertensive activity. All the synthesized compounds of the series displayed, remarkable activity in comparison to standard drug(losratan ). Many Schiff bases were prepare...
متن کاملBenzimidazoles derivatives with (2-{6-Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl- 4-ylmethyl] 1H-benzoimidazol-2-yl}-phenyl)-(substituted-benzylidene)-amine with potential angiotensin II receptor antagonists as antihypertensive activity
Mukesh C. Sharma Dept. of Pharmaceutical Sciences, Dr.Hari Singh Gour University Sagar (M.P) 470003 India Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P) 477001 India Email: [email protected] Abstract In this study we have synthesized some Benzimidazole derivatives (2-{6Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1Hbenzoimidazol-2-yl}-phenyl)-(Substituted-benzyl...
متن کامل